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Print Operating Characteristics of a Backfill Design Across Scenarios

Source: R/print.backfill_oc_multi.R
print.backfill_oc_multi.Rd

Display the result of sim_bf_boin_multi or sim_be_boin_multi as one table with seven rows per scenario.

Usage

# S3 method for class 'backfill_oc_multi'
print(
  x,
  digits = 1,
  percent = FALSE,
  kable = FALSE,
  kable_format = "pipe",
  ...
)

Arguments

x

An object of class backfill_oc_multi.

digits

Integer scalar. Number of decimal places. Defaults to 1.

percent

Logical scalar. Show patients, backfilled patients and DLTs as percentages of their totals. Defaults to FALSE.

kable

Logical scalar. Print only the table, formatted by knitr::kable(). Defaults to FALSE.

kable_format

Character scalar passed to knitr::kable() as format. Defaults to "pipe".

...

Further arguments, currently ignored.

Value

The object x, invisibly.

See also

sim_bf_boin_multi, sim_be_boin_multi

Examples

scenarios <- list(
  list(name = "Rising", p_true = c(0.04, 0.12, 0.25, 0.43, 0.63),
       p_resp = c(0.10, 0.20, 0.30, 0.45, 0.58)),
  list(name = "Plateau", p_true = c(0.04, 0.12, 0.25, 0.43, 0.63),
       p_resp = c(0.30, 0.32, 0.35, 0.36, 0.36))
)
oc <- sim_bf_boin_multi(
  target = 0.25, scenarios = scenarios, n_cohort = 10, cohort_size = 3,
  window = 1, accrual_rate = 3, n_trials = 100, seed = 1
)
print(oc, percent = TRUE)
#> BF-BOIN operating characteristics across 2 scenarios
#>   target DLT rate : 0.25
#>   trials each     : 100
#>   escalation size : 30
#>   backfill cap    : 12 patients per dose
#>   window          : 1 (DLT), 1 (response)
#>   accrual         : 3 patients per unit of time (exponential)
#> 
#>  Scenario                    Item  DL1  DL2  DL3  DL4  DL5 Total / No MTD
#>    Rising       True DLT rate (%)  4.0 12.0 25.0 43.0 63.0               
#>            True response rate (%) 10.0 20.0 30.0 45.0 58.0               
#>                  MTD selected (%)  2.0 25.0 64.0  9.0  0.0            0.0
#>              Patients treated (%) 23.0 36.2 31.4  8.6  0.8           38.2
#>           Backfilled patients (%)  7.5  9.7  5.0  0.6  0.0           22.8
#>             Patients with DLT (%)  6.4 25.5 42.9 22.6  2.6            6.9
#>             Trial duration (mean)                                    17.1
#>   Plateau       True DLT rate (%)  4.0 12.0 25.0 43.0 63.0               
#>            True response rate (%) 30.0 32.0 35.0 36.0 36.0               
#>                  MTD selected (%)  2.0 30.0 56.0 12.0  0.0            0.0
#>              Patients treated (%) 25.6 35.5 29.2  8.6  1.1           40.2
#>           Backfilled patients (%) 11.0 11.2  4.6  0.7  0.0           27.5
#>             Patients with DLT (%)  6.6 26.5 40.7 22.6  3.6            7.0
#>             Trial duration (mean)                                    17.2