Package index

Decision rules

Boundaries and decision tables of the BOIN design.

boin_lambda()

Escalation and De-escalation Interval Boundaries

boin_p_tox()

Toxic Threshold Giving a Required De-escalation Boundary

boin_boundary()

Integer Decision Boundaries for the BOIN Design

print(<boin_boundary>)

Print BOIN Decision Boundaries

as.data.frame(<boin_boundary>)

Coerce BOIN Decision Boundaries to a Data Frame

boin_decision_table()

Decision Table for the BOIN Design

print(<boin_decision_table>)

Print a BOIN Decision Table

plot(<boin_decision_table>)

Plot a BOIN Decision Table

boin_stopping_table()

Safety Stopping Boundary as a Two-Row Table

Single-agent BOIN design

Operating characteristics, simulated trials and selection of the MTD.

sim_boin()

Operating Characteristics of a BOIN Design

sim_boin_multi()

Operating Characteristics Across Several Scenarios

boin_simulate()

Simulate BOIN Trials

boin_isotonic()

Isotonic Estimates of the DLT Probability

boin_select_mtd()

Select the MTD from Completed Trials

print(<boin_oc>)

Print Operating Characteristics of a BOIN Design

print(<boin_oc_multi>)

Print Operating Characteristics Across Scenarios

print(<boin_trials>)

Print Simulated BOIN Trials

Late-onset toxicity (TITE-BOIN)

tite_boin_decision_table()

Decision Table for the TITE-BOIN Design

print(<tite_boin_decision_table>)

Print a TITE-BOIN Decision Table

plot(<tite_boin_decision_table>)

Plot a TITE-BOIN Decision Table

sim_tite_boin()

Operating Characteristics of a TITE-BOIN Design

sim_tite_boin_multi()

Operating Characteristics of a TITE-BOIN Design Across Several Scenarios

tite_boin_simulate()

Simulate TITE-BOIN Trials

print(<tite_boin_oc>)

Print Operating Characteristics of a TITE-BOIN Design

print(<tite_boin_oc_multi>)

Print Operating Characteristics of a TITE-BOIN Design Across Scenarios

print(<tite_boin_trials>)

Print Simulated TITE-BOIN Trials

Backfilling (BF-BOIN and BE-BOIN)

sim_bf_boin()

Operating Characteristics of a BF-BOIN Design

sim_bf_boin_multi()

Operating Characteristics of a BF-BOIN Design Across Several Scenarios

bf_boin_simulate()

Simulate BF-BOIN Trials

sim_be_boin()

Operating Characteristics of a BE-BOIN Design

sim_be_boin_multi()

Operating Characteristics of a BE-BOIN Design Across Several Scenarios

be_boin_simulate()

Simulate BE-BOIN Trials

print(<backfill_oc>)

Print Operating Characteristics of a BOIN Design with Backfilling

print(<backfill_oc_multi>)

Print Operating Characteristics of a Backfill Design Across Scenarios

print(<backfill_trials>)

Print Simulated Trials of a BOIN Design with Backfilling

Drug combinations

sim_comb_boin()

Operating Characteristics of the BOIN Drug-Combination Design

sim_comb_boin_multi()

Operating Characteristics of the BOIN Drug-Combination Design Across Scenarios

comb_boin_simulate()

Simulate BOIN Drug-Combination Trials

comb_boin_select_mtd()

Select the MTD Combination from Completed Drug-Combination Trials

comb_boin_next()

Next Dose Combination in a BOIN Drug-Combination Trial

print(<comb_boin_oc>)

Print Operating Characteristics of the BOIN Drug-Combination Design

print(<comb_boin_oc_multi>)

Print Operating Characteristics of the BOIN Drug-Combination Design Across Scenarios

print(<comb_boin_trials>)

Print Simulated BOIN Drug-Combination Trials

print(<comb_boin_next>)

Print the Next Dose Combination of a BOIN Drug-Combination Trial

plot(<comb_boin_next>)

Plot the Next Dose Combination of a BOIN Drug-Combination Trial

The 3+3 design

oc_3p3()

Exact Operating Characteristics of the 3+3 Design

print(<oc_3p3>)

Print Operating Characteristics of the 3+3 Design

sim_3p3()

Simulate the 3+3 Design

decision_table_3p3()

Decision Table for the 3+3 Design

print(<decision_table_3p3>)

Print a 3+3 Decision Table

plot(<decision_table_3p3>)

Plot a 3+3 Decision Table