Print Operating Characteristics of the BOIN Drug-Combination Design
Source:R/print.comb_boin_oc.R
print.comb_boin_oc.RdDisplay the summary produced by sim_comb_boin: the true DLT
rates, the selection percentages and the average numbers of patients and
DLTs at every dose combination, followed by the selection of the true MTD
and the exposure to combinations above the overdose cutoff.
Usage
# S3 method for class 'comb_boin_oc'
print(x, digits = 1, kable = FALSE, kable_format = "pipe", ...)Arguments
- x
An object of class
comb_boin_oc.- digits
Integer scalar. Number of decimal places. Defaults to 1.
- kable
Logical scalar. Return the table through
knitr::kable()rather than printing it directly, which is convenient inside a report. Requires the knitr package. Defaults toFALSE.- kable_format
Character scalar passed to
knitr::kable(), for example"pipe","html"or"latex". Defaults to"pipe".- ...
Further arguments, currently ignored.
Examples
p_true <- matrix(c(0.02, 0.04, 0.08, 0.14,
0.08, 0.25, 0.42, 0.48,
0.25, 0.45, 0.50, 0.60), nrow = 3, byrow = TRUE)
oc <- sim_comb_boin(
target = 0.25,
p_true = p_true,
n_cohort = 16,
cohort_size = 3,
n_trials = 200,
seed = 123
)
print(oc)
#> BOIN drug-combination operating characteristics
#> target DLT rate : 0.25
#> dose levels : 3 of drug A, 4 of drug B
#> trials : 200
#> cohorts : 16 of size 3
#> max sample size : 48
#> lambda_e / _d : 0.1968 / 0.2984
#>
#> Item Drug A B1 B2 B3 B4
#> True DLT rate (%) A1 2.0 4.0 8.0 14.0
#> A2 8.0 25.0 42.0 48.0
#> A3 25.0 45.0 50.0 60.0
#> MTD selected (%) A1 0.0 1.0 5.0 16.0
#> A2 3.0 37.0 10.0 0.5
#> A3 20.5 7.0 0.0 0.0
#> Patients treated A1 4.0 3.7 2.7 2.8
#> A2 5.8 9.0 3.9 1.5
#> A3 4.7 4.0 1.0 0.3
#> Patients with DLT A1 0.1 0.2 0.2 0.4
#> A2 0.4 2.1 1.6 0.7
#> A3 1.2 1.7 0.5 0.2
#>
#> No MTD selected : 0%
#> Average number of patients : 43.6
#> Average number of DLTs : 9.4
#>
#> True MTD (closest to the target) : A3B1, A2B2
#> Selected as the MTD : 57.5%
#> Patients treated there : 31.6%
#>
#> Combinations above a true DLT rate of 0.25: 5 of 12
#> Patients treated there : 24.8%
#> Trials treating any patient there : 82%
#> Trials treating over 60% there : 2.5%
#> Trials treating over 80% there : 0.5%
#> Trials selecting an MTD there : 17.5%
print(oc, digits = 2)
#> BOIN drug-combination operating characteristics
#> target DLT rate : 0.25
#> dose levels : 3 of drug A, 4 of drug B
#> trials : 200
#> cohorts : 16 of size 3
#> max sample size : 48
#> lambda_e / _d : 0.1968 / 0.2984
#>
#> Item Drug A B1 B2 B3 B4
#> True DLT rate (%) A1 2.00 4.00 8.00 14.00
#> A2 8.00 25.00 42.00 48.00
#> A3 25.00 45.00 50.00 60.00
#> MTD selected (%) A1 0.00 1.00 5.00 16.00
#> A2 3.00 37.00 10.00 0.50
#> A3 20.50 7.00 0.00 0.00
#> Patients treated A1 3.98 3.70 2.71 2.84
#> A2 5.80 9.03 3.93 1.50
#> A3 4.74 4.04 1.03 0.30
#> Patients with DLT A1 0.07 0.18 0.18 0.41
#> A2 0.40 2.12 1.65 0.72
#> A3 1.22 1.73 0.50 0.20
#>
#> No MTD selected : 0%
#> Average number of patients : 43.6
#> Average number of DLTs : 9.37
#>
#> True MTD (closest to the target) : A3B1, A2B2
#> Selected as the MTD : 57.5%
#> Patients treated there : 31.58%
#>
#> Combinations above a true DLT rate of 0.25: 5 of 12
#> Patients treated there : 24.77%
#> Trials treating any patient there : 82%
#> Trials treating over 60% there : 2.5%
#> Trials treating over 80% there : 0.5%
#> Trials selecting an MTD there : 17.5%