Changelog
Source:NEWS.md
CorOncoEndpoints 0.1.0
Initial Release
This is the first release of the CorOncoEndpoints package, providing comprehensive tools for generating correlated oncology endpoints in clinical trial simulations.
Main Features
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Data Generation
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rOncoEndpoints(): Generate correlated OS, PFS, and Response endpoints - Support for 7 different endpoint patterns (OS only, PFS only, Response only, OS+Response, PFS+Response, OS+PFS, OS+PFS+Response)
- Multi-group support for comparing multiple treatment arms
- Automatic enforcement of PFS ≤ OS constraint
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Copula Support
- Clayton copula (lower tail dependence, positive correlations only)
- Frank copula (flexible symmetric dependence, positive and negative correlations)
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Validation Tools
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CheckSimResults(): Validate simulation results against theoretical values - Calculate bias, relative bias, SE, MSE, and RMSE
- Compare empirical estimates with theoretical expectations
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Correlation Analysis
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CorResponsePFS(): Calculate PFS-Response correlation in OS-PFS-Response framework -
CorBoundResponsePFS(): Compute correlation bounds for PFS-Response -
CorBoundResponseTTE(): Compute general correlation bounds for TTE-Response -
CopulaParamResponseTTE(): Calculate copula parameters for given correlations
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Theoretical Framework
- Implementation of Fleischer model (2009) for OS-PFS dependency
- Fréchet-Hoeffding bounds for correlation constraints
- Copula-based dependence modeling